alpha2 - Adrenergic Receptors (NE)

Inhibition of adenylyl cyclase by agonists that bind to alpha2-adrenergic receptors.
Alpha2 adrenoceptor ligands inhibit adenylyl cyclase by causing dissociation of the inhibitory G protein, Gi, into its subunits; ie, an alphai subunit charged with GTP and a beta-gamma unit. The mechanism by which these subunits inhibit adenylyl cyclase is uncertain.
alpha2-adrenergic receptors cause specific actions in the following organs:

Adapted from Figure 9-2: StatRef Online Library: Basic and Clinical Pharmacology 8th ed. (2001)
by Michael Bolger, 8/26/01
Copyright(c) 2001 The McGraw Hill Companies, Inc. All rights reserved

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