Activation of adenylyl cyclase by agonists that bind to D1-dopaminergic receptors.
Binding to D1-adrenoceptors stimulates adenylyl cyclase by activating the stimulatory G protein, Gs, which leads to the dissociation of its alpha subunit charged with GTP. This alpha subunit directly activates adenylyl cyclase, resulting in an increased rate of synthesis of cAMP. These catalytic units also phosphorylate the cAMP response element binding protein (CREB), which modifies gene expression.
D1-dopaminergic receptors cause vasodilation in the kidney.
Adapted from Figure 9-2: StatRef Online Library: Basic and Clinical Pharmacology 8th ed. (2001)
by Michael Bolger, 8/26/01
Copyright(c) 2001 The McGraw Hill Companies, Inc. All rights reserved
Last updated 8/26/01
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