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For collaboration, consultation, or custom applications contact:
Michael B. Bolger, Ph.D. at:
bolger@usc.edu

Cyber Patient ^(TM) Abstract:

The Cyber Patient: A Multimedia Pharmacokinetic Simulation Program for Case Study Generation in a Problem-Solving Curriculum. Michael B. Bolger, Simulations Plus, Inc., Lancaster, CA Cyber Patient is a multimedia pharmacokinetic (PK) simulation program that can be used for development and presentation of problem-solving case studies. This simulation program is appropriate for use in pharmacy or medical schools to assist the instructor in development of PK drug models. The PK drug models are used by students to generate their own data for use in a problem-solving curriculum. In addition, Cyber Patient can be used in the pharmaceutical industry for pharmacokinetic drug simulations. The Cyber Patient simulation is an MS-Windows program based on a numerical method for solution of the differential equations that describe one and two compartment models. The simulation places the user in the role of a health care professional that has primary care responsibility for a patient who is taking medication. The user can load a PK model from the disk or create a model by entering the appropriate PK parameters into text boxes on the main screen. A patient view menu can be programmed by the instructor to contain a sound (.WAV) or video (.AVI) files that describes the patient's condition. When blood levels are too low the user observes a "sick" patient and when therapeutic blood levels are achieved, the user observes a "treated" patient. However, if blood levels get too high the patient can be programmed to have a "toxic" reaction. Each time the simulation is run, the user must select five time points for collection of drug level data from the central compartment. Following the simulation, blood level data is displayed in graphical format as well as being placed in the Windows clipboard (with random error) for convenient pasting into another application or spreadsheet for determination of the best fit parameters. In addition to the simulation of pharmacokinetics, Cyber Patient contains an extensive help system that is a "hypertext" introduction to basic pharmacokinetics. The Help system allows the user to search for information about pharmacokinetic terms and to follow "hypertext" links from one topic to the next.

How to download and install freeware version of Cyber Patient

Cyber Patient 1.12
5/4/12
Copyright (c) LabSoft Solutions 1995 - 2012
written by Michael B. Bolger, Ph.D.

Welcome to the Cyber Patient pharmacokinetic drug simulation program. You will find the compressed ".zip" file "CyberPatiSetupFiles_zip" to be the easiest method for generating the Windows XP setup files. Change the file name from "CyberPatiSetupFiles_zip" to "CyberPatiSetupFiles.zip" in a clean subdirectory.
Download a copy of Version 1.2 now.
To install this program and the various support files start MS-Windows XP and run the SETUP.EXE program. This will copy the .DLL, .VBX files and the Graphics Server program to your Windows/System subdirectory. It will ask where you would like for the Cyber Patient to be installed. The default is C:\Program Files\CybrPati\. When the installation is complete you should make a directory for media files called C:\Program Files\CybrPati\MEDIA. Then you should move all of the .WAV, and .BMP files to that subdirectory. In addition to Cyber Patient, you will find two MS-Excel spreadsheets "1CMPART.XLS" and "2CMPART.XLS" that can be used with SOLVER to determine the pharmacokinetic parameters of a data set generated by the Cyber Patient. After each run of the simulation, Cyber Patient places its kinetic data on the Windows clipboard for convenient pasting into other applications. Please see fixes.txt for changes from version 1.1.

For additional information contact:
Michael B. Bolger, Ph.D. at:
bolger@usc.edu

PharmLab ^(TM) Abstract:

A Computer Program for the Calculation and Visualization of Drug Degradation pH Rate Profiles

Michael B. Bolger and Ian S. Haworth
PharmLabTM is an MS-Windows program that computes a time course for drug degradation and can be used to calculate a pH rate profile for a drug. We have used the program in an educational setting to illustrate and examine the kinetics of the hydrolysis of ionizable esters as a function of the molecular structure of the ester. In addition to the educational value, we believe that the simple relationships used to parameterize the program provide some new insights into the pH rate profile for ester hydrolysis, and could offer an accurate predictive method, given a broader-based parameterization. The program is based on experimental rate profiles and on numerical integration of the differential equations that describe the hydrolysis of ionizable esters. The influence of the pKa of the ionizable group on the experimental rate profiles follows from standard differential rate equations. Empirical parameters derived as a function of the pKa values of the reactants and products in the hydrolysis reaction were used to calculate changes in rate constants caused by changes in the molecular structure. We illustrate the derivation of these parameters for a series of esters structurally similar to procaine (2-(N,N-diethylamino)ethyl 4-aminobenzoate), and show how the pH rate profiles we obtain can be interpreted in terms of the structural differences between the esters.

How to download and install freeware version of PharmLab

PharmLab 1.2
5/4/12
Copyright (c) LabSoft Solutions 1996 - 2012
written by Michael B. Bolger, Ph.D.

Welcome to the PharmLab - Drug Degradation pH Rate Profile simulation program. You will find the compressed ".zip" file "PharmLabSetupFiles_zip" to be the easiest method for generating the Windows XP setup files. Change the file name from "PharmLabSetupFiles_zip" to "PharmLabSetupFiles.zip" in a clean subdirectory.
Download a copy of Version 1.2 now.
To install this program and the various support files start MS-Windows XP and run the SETUP.EXE program. This will copy the .DLL, .VBX files and the Graphics Server program to your Windows/System subdirectory. It will ask where you would like for the Cyber Patient to be installed. The default is C:\Program Files\PharmLab\. When the installation is complete you should make a directory for media files called C:\Program Files\PharmLab\MEDIA. Then you should move all of the .WAV, .BMP, and .WMF files to that subdirectory. In addition to PharmLab, you will find two MS-Excel spreadsheets "PROCAINE.XLS" and "ASPRIN.XLS" that can be used to see the algorithm used for generating the pH rate profile information. After each run of the simulation, PharmLab places its kinetic data on the Windows clipboard for convenient pasting into other applications.

For additional information contact:
Michael B. Bolger, Ph.D. at:
bolger@usc.edu

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